Central and Peripheral Pathways
The cause of chronic cough is thought to be the result of a hypersensitivity disorder where a stimulus, either chemical or mechanical, sends a message to the brain, through the brainstem, resulting in a cough. It is believed that IPF patients have an increased sensitivity to cough stimuli resulting in chronic cough. Since kappa and mu receptors are found in the respiratory regions of the brain, brainstem, lungs, and peripheral lung nerves, it is hypothesized that Haduvio can block the cough signal centrally and as well as peripherally and result in cough reduction independent of the initial stimuli.
Due to its dual mechanism of action (MOA), we believeHaduviois well suited to address chronic cough across a variety of conditions.
For more information on our global clinical development programs, please visit our Pipeline page.
